Four New Cuparene‐Type Sesquiterpenes from <i>Flammulina velutipes</i>

Abstract

Abstract Flamvelutpenoids A–D ( 1 – 4 ), four new cuparene‐type sesquiterpenes, were isolated from the solid culture of Flammulina velutipes. Their structures were elucidated by NMR experiments. The absolute configurations of 1 and 2 were assigned via the circular dichroism data of the [Rh 2 (OCOCF 3 ) 4 ] complex, whereas that of C(3) of 3 was determined by applying the octant rule for the α , β ‐unsaturated ketone moiety. Compounds 1 – 4 showed weak antibacterial activity against Escherichia coli, Bacillus subtilis , and methicillin‐resistant Staphylococcus aureus with MIC values larger than 100 μ M .