Concepedia

Synthesis of 26,26,26,27,27,27-hexafluoro-25-hydroxyvitamin D3

Yoshiro Kobayashi, Takeo Taguchi, N. KANUMA, Nobuo Ikekawa, Jun‐ichi Oshida

Journal of the Chemical Society Chemical Communications · 1980 · 27 citations · 0 references

Concepts

Medicinal ChemistryEngineeringBiochemistryVitamin D3Natural SciencesOrganic ChemistrySynthetic ChemistryPharmacology26,26,26,27,27,27-Hexafluoro-25-hydroxyvitamin D3Biomolecular Engineering24-Tosyloxy-25,26,27-trinorcholest-5-en-3β-yl Tetrahydropyranyl Ether

Abstract

In order to investigate the biological significance of 26-hydroxylation of vitamin D3, 26,26,26,27,27,27-hexafluoro-25-hydroxyvitamin D3 was prepared from 24-tosyloxy-25,26,27-trinorcholest-5-en-3β-yl tetrahydropyranyl ether.