Toxicity Studies of the Aqueous Root Extract of <i>Lecaniodiscus cupanioides</i>

Abstract

The aqueous root extract of Lecaniodiscus cupanioides was used to study the toxicity pattern of the plant. The extract was found to be non-toxic up to 20g/kg, when given by the oral route to mice within 24h and for additional 14 days. Acute (24h, i.p.) toxicity test, however, produced a dose dependent mortality with LD50 of 455.2+3.6 mg/kg. Subchronic (45 days) oral toxicity tests in rats did not show any mortality, and there was no significant (P