Somatostatin Analogs Modulate AIP in Somatotroph Adenomas: The Role of the ZAC1 Pathway - Concepedia

Concepedia

Publication | Open Access

Somatostatin Analogs Modulate AIP in Somatotroph Adenomas: The Role of the ZAC1 Pathway

DOI Full Paper Access

139

Citations

38

References

2012

Year

Harvinder Chahal, Giampaolo Trivellin, Chrysanthia A. Leontiou, Neda Alband, Robert C. Fowkes, Asil Tahir, Susana Igreja, J. Paul Chapple, Susan J. Jordan, Amelie Lupp,

The Journal of Clinical Endocrinology & Metabolism

Abstract

These results suggest that AIP may play a role in the mechanism of action of somatostatin analogs via ZAC1 in sporadic somatotroph tumors and may explain their lack of effectiveness in patients with AIP mutations.

References

	Year	Citations
Pensar y educar W. Remmele, H.-E. Stegner Paideia: Revista de filosofía y didáctica filosófica	1987	2K
Pituitary Adenoma Predisposition Caused by Germline Mutations in the <i>AIP</i> Gene Outi Vierimaa, Marianthi Georgitsi, Rainer Lehtonen, Science Human GrowthGeneticsGenetic EpidemiologyPathologyMolecular Genetics	2006	604
Dioxin receptor is a ligand-dependent E3 ubiquitin ligase Fumiaki Ohtake, Atsushi Baba, Ichiro Takada, Nature Heme SignalingCell SignalingMolecular BiologyDioxin Receptor	2007	569
Clinical Characteristics and Therapeutic Responses in Patients with Germ-Line<i>AIP</i>Mutations and Pituitary Adenomas: An International Collaborative Study Adrian Daly, María A. Tichomirowa, Patrick Pétrossians, The Journal of Clinical Endocrinology & Metabolism	2010	361
Aryl Hydrocarbon Receptor-Interacting Protein Gene Mutations in Familial Isolated Pituitary Adenomas: Analysis in 73 Families Adrian F. Daly, Jean-François Vanbellinghen, Sok Kean Khoo, The Journal of Clinical Endocrinology & Metabolism	2007	320
The Role of the Aryl Hydrocarbon Receptor-Interacting Protein Gene in Familial and Sporadic Pituitary Adenomas Chrysanthia A. Leontiou, Maria Gueorguiev, Jacqueline van der Spuy, The Journal of Clinical Endocrinology & Metabolism	2008	293
Regulation of apoptosis and cell cycle arrest by Zac1, a novel zinc finger protein expressed in the pituitary gland and the brain Dietmar Spengler The EMBO Journal Signal TransductionDevelopmental BiologyCell DivisionPituitary GlandCell Signaling	1997	241
Octreotide, a Somatostatin Analogue, Mediates Its Antiproliferative Action in Pituitary Tumor Cells by Altering Phosphatidylinositol 3-Kinase Signaling and Inducing Zac1 Expression Marily Theodoropoulou, Jing Zhang, S Laupheimer, Cancer Research	2006	210
Characterization of aryl hydrocarbon receptor interacting protein (AIP) mutations in familial isolated pituitary adenoma families Susana Igreja, Harvinder S. Chahal, Peter King, Human Mutation	2010	178
High prevalence of AIP gene mutations following focused screening in young patients with sporadic pituitary macroadenomas María A. Tichomirowa, Anne Barlier, Adrian Daly, European Journal of Endocrinology	2011	167

Page 1