Diminished Prostaglandin E <sub>2</sub> Contributes to the Apoptosis Paradox in Idiopathic Pulmonary Fibrosis - Concepedia

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Diminished Prostaglandin E <sub>2</sub> Contributes to the Apoptosis Paradox in Idiopathic Pulmonary Fibrosis

DOI Full Paper Access

186

Citations

42

References

2010

Year

Toby M. Maher, Iona Evans, Stephen E. Bottoms, Paul F. Mercer, Andrew J. Thorley, Andrew G. Nicholson, Geoffrey J. Laurent, Teresa D. Tetley, Rachel C. Chambers, Robin J. McAnulty

American Journal of Respiratory and Critical Care Medicine

Abstract

The observation that PGE(2) deficiency results in increased AEC but reduced fibroblast sensitivity to apoptosis provides a novel pathogenic insight into the mechanisms driving persistent fibroproliferation in IPF.

References

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