Concepedia

Diminished Prostaglandin E <sub>2</sub> Contributes to the Apoptosis Paradox in Idiopathic Pulmonary Fibrosis

Toby M. Maher, Iona Evans, Stephen E. Bottoms, Paul F. Mercer, Andrew J. Thorley, Andrew G. Nicholson, Geoffrey J. Laurent, Teresa D. Tetley, Rachel C. Chambers, Robin J. McAnulty

American Journal of Respiratory and Critical Care Medicine · 2010 · 186 citations · 42 references

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Abstract

The observation that PGE(2) deficiency results in increased AEC but reduced fibroblast sensitivity to apoptosis provides a novel pathogenic insight into the mechanisms driving persistent fibroproliferation in IPF.

References

42

Alveolar epithelial cell mesenchymal transition develops <i>in vivo</i> during pulmonary fibrosis and is regulated by the extracellular matrix

Kevin K. Kim, Matthias C. Kugler, Paul J. Wolters et al. · Proceedings of the National Academy of Sciences · 2006 · 1.2K citations · Full text

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Histopathologic Subsets of Fibrosing Alveolitis in Patients with Systemic Sclerosis and Their Relationship to Outcome

Demosthenes Bouros, Athol U. Wells, Andrew G. Nicholson et al. · American Journal of Respiratory and Critical Care Medicine · 2002 · 809 citations

Akt Phosphorylation and Stabilization of X-linked Inhibitor of Apoptosis Protein (XIAP)

Han C. Dan, Mei Sun, Satoshi Kaneko et al. · Journal of Biological Chemistry · 2004 · 424 citations · Full text

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Cultured lung fibroblasts isolated from patients with idiopathic pulmonary fibrosis have a diminished capacity to synthesize prostaglandin E2 and to express cyclooxygenase-2.

J Wilborn, Leslie J. Crofford, Marie D. Burdick et al. · Journal of Clinical Investigation · 1995 · 391 citations

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The CD95 Receptor: Apoptosis Revisited

Marcus E. Peter, Ralph C. Budd, Julie Desbarats et al. · Cell · 2007 · 389 citations · Full text

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