Enzyme-independent formation of nitric oxide in biological tissues

The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine

Robert F. Furchgott, John V. Zawadzki · Nature · 1980 · 12K citations

Mechanobiology, Obligatory Role, Molecular Physiology +12

Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor

Richard Palmer, Anthony G. Ferrige, Salvador Moncada · Nature · 1987 · 10.7K citations

Inflammation, Biological Activity, Endothelium-derived Relaxing Factor +8

Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide.

Joseph S. Beckman, ThomasJ Beckman, Jake Y. Chen et al. · Proceedings of the National Academy of Sciences · 1990 · 7K citations · Full text

Inflammation, Peroxynitrite Decomposition, Redox Signaling +15

Cloned and expressed nitric oxide synthase structurally resembles cytochrome P-450 reductase

David S. Bredt, Paul M. Hwang, Charles E. Glatt et al. · Nature · 1991 · 2.4K citations

Biochemistry, Reactive Nitrogen Specie, Natural Sciences +6

Endothelium‐derived relaxing and contracting factors

Robert F. Furchgott, Paul M. Vanhoutte · The FASEB Journal · 1989 · 2K citations