Ritonavir, Triglycerides, and Pancreatitis

Abstract

Brief Reports AmB (0.1 mg every other day) was given through an Omaya of the medication for a long period and yet preserve renal function.reservoir (total dose, 1.2 mg), hyperbaric oxygen therapy was con-The worsening renal function seen at the end of treatment might tinued, and G-CSF therapy (5 mg/[kgrd]) was restarted.have been related to the high cumulative dose of ABLC or to Follow-up MRI on day 60 showed persistent abnormal enhancethe use of the nonsteroidal antiinflammatory drug, leading to a ment of the left cavernous sinus and left frontal lobe, and biopsy hypersensitivity reaction. of the left orbital fossa showed persistent nonseptated hyphae;Six months after therapy was stopped, his renal function has culture was negative.As a result, the ABLC dosage was increased improved remarkably.G-CSF was given at a dosage of to 10 mg/(kgrd) for 2 months and then slowly tapered over 3 5 mg/(kgrd) in an attempt to improve the presumed abnormal months.Total doses of 1.8 g of AmB and 60.3 g of ABLC were neutrophil function.The only adverse effect seen with prolonged given in a 7-month period.A sharp increase in the creatinine level, therapy was mild bone pain.The combined approach used to treat from 1.8 mg/dL to 5 mg/dL (after 7 months of treatment), prompted this patient suggests new strategies for this disease, which is genercessation of therapy.ally associated with such a poor prognosis.At the time of renal impairment, the patient also developed rash and fever concurrent with the use of a nonsteroidal anti-J.Milton Gaviria, Lisa A. Grohskopf, Robert Barnes, and inflammatory drug, a circumstance raising the question of whether Richard K. Root the renal failure was a consequence of a hypersensitivity reaction Division of Allergy and Infectious Diseases, Department of Internal rather than due to ABLC toxicity.G-CSF (5 mg/[kgrd]) was given