Convergent combination therapy can select viable multidrug-resistant HIV-1 in vitro

HIV with Reduced Sensitivity to Zidovudine (AZT) Isolated During Prolonged Therapy

B. A. Larder, G. Darby, Douglas D. Richman · Science · 1989 · 1.6K citations

Medicine, Infectious Diseases, Pharmacology +17

Multiple Mutations in HIV-1 Reverse Transcriptase Confer High-Level Resistance to Zidovudine (AZT)

Brendan Larder, Sharon D. Kemp · Science · 1989 · 1.2K citations

Life Sciences, Microbiology, Molecular Genetics +17

Inhibition of HIV-1 Replication by a Nonnucleoside Reverse Transcriptase Inhibitor

Vincent J. Merluzzi, Karl D. Hargrave, Mark E. Labadia et al. · Science · 1990 · 746 citations

Life Sciences, Medicinal Chemistry, Molecular Biology +17

Resistance to ddI and Sensitivity to AZT Induced by a Mutation in HIV-1 Reverse Transcriptase

M H St Clair, J L Martin, Gareth Tudor‐Williams et al. · Science · 1991 · 681 citations

Life Sciences, Infectious Diseases, Pharmacology +17

Rapid in vitro selection of human immunodeficiency virus type 1 resistant to 3'-thiacytidine inhibitors due to a mutation in the YMDD region of reverse transcriptase.

Margaret Tisdale, Sharon D. Kemp, N. R. Parry et al. · Proceedings of the National Academy of Sciences · 1993 · 608 citations

Life Sciences, Infectious Diseases, Molecular Genetics +17