Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in <i>Tlr4</i> Gene

Alexander Poltorak, Xiaolong He, Irina Smirnova, +11

Science

A Toll-like receptor recognizes bacterial DNA

Hiroaki Hemmi, Osamu Takeuchi, Taro Kawai, +8

Nature

Toll-like ReceptorsVirulence FactorPathogenesisInnate Immune SystemToll-like Receptor +5

Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3

Lena Alexopoulou, Agnieszka Czopik Holt, Ruslan Medzhitov, +1

Nature

InflammationToll-like ReceptorsMolecular ImmunologyCytokineAllergy +12

CpG motifs in bacterial DNA trigger direct B-cell activation

Arthur Μ. Krieg, Ae‐Kyung Yi, Sara Matson, +5

Nature

Natural SciencesVirulence FactorCpg MotifsMolecular BiologyDna Replication +2

Quantitative Expression of Toll-Like Receptor 1–10 mRNA in Cellular Subsets of Human Peripheral Blood Mononuclear Cells and Sensitivity to CpG Oligodeoxynucleotides

Veit Hornung, Simon Rothenfußer, Stefanie Britsch, +5

The Journal of Immunology

Oral bacteriotherapy as maintenance treatment in patients with chronic pouchitis: A double-blind, placebo-controlled trial

Paolo Gionchetti, Fernando Rizzello, Alessandro Venturi, +6

Gastroenterology

Antimicrobial StewardshipOral BacteriotherapyRespiratory InfectionPlacebo-controlled TrialInfection Control +4

Resident Enteric Bacteria Are Necessary for Development of Spontaneous Colitis and Immune System Activation in Interleukin-10-Deficient Mice

Rance K. Sellon, Susan L. Tonkonogy, Michael Schultz, +5

Infection and Immunity

Cutting Edge: Bacterial Flagellin Activates Basolaterally Expressed TLR5 to Induce Epithelial Proinflammatory Gene Expression

Andrew T. Gewirtz, Tony Navas, Sean Lyons, +2

The Journal of Immunology

A distinct array of proinflammatory cytokines is expressed in human colon epithelial cells in response to bacterial invasion.

Hyun Chae Jung, Lars Eckmann, Shen K. Yang, +4

Journal of Clinical Investigation

Enterocolitis and colon cancer in interleukin-10-deficient mice are associated with aberrant cytokine production and CD4(+) TH1-like responses.

Daniel Berg, N Davidson, Ralf Kühn, +6

Journal of Clinical Investigation

ImmunologyImmune RegulationPathologyImmunologic MechanismCd4 T Cell Responses +18