Concepedia

Severe impairment of anti-cancer effect of lipoteichoic acid-related molecule isolated from a penicillin-killed Streptococcus pyogenes in toll-like receptor 4-deficient mice

Masato Okamoto, Tetsuya Oshikawa, Go Ohe, Hidetomo Nishikawa, Sachiko Furuichi, Tomoyuki Tano, Yoichiro Moriya, Motoo Saito, Mitsunobu Sato

International Immunopharmacology · 2001 · 44 citations · 20 references

Concepts

Toll-like ReceptorsLipoteichoic Acid-related MoleculeAntimicrobial SusceptibilityAntibioticsMedicineImmunologyAnti-cancer EffectMicrobiologySevere ImpairmentAntimicrobial CompoundAntibiotic ResistancePharmacologyAntimicrobial ResistanceDrug DiscoveryDrug Resistance

References

20

Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in <i>Tlr4</i> Gene

Alexander Poltorak, Xiaolong He, Irina Smirnova et al. · Science · 1998 · 7.5K citations

A human homologue of the Drosophila Toll protein signals activation of adaptive immunity

Ruslan Medzhitov, Paula Preston‐Hurlburt, Charles A. Janeway · Nature · 1997 · 5.5K citations

Host Response, Toll-like Receptors, Signal Transduction +10

Cutting Edge: Toll-Like Receptor 4 (TLR4)-Deficient Mice Are Hyporesponsive to Lipopolysaccharide: Evidence for TLR4 as the <i>Lps</i> Gene Product

Katsuaki Hoshino, Osamu Takeuchi, Taro Kawai et al. · The Journal of Immunology · 1999 · 3.4K citations · Full text

Differential Roles of TLR2 and TLR4 in Recognition of Gram-Negative and Gram-Positive Bacterial Cell Wall Components

Osamu Takeuchi, Katsuaki Hoshino, Taro Kawai et al. · Immunity · 1999 · 3.3K citations · Full text

Toll-like Receptors, Gram-negative Bacteriology, Virulence Factor +7

TLR4 mutations are associated with endotoxin hyporesponsiveness in humans

Nancy C. Arbour, Eva Lorenz, Brian C. Schutte et al. · Nature Genetics · 2000 · 2K citations

Toll-like Receptors, Immunogenetics, Pathogenesis +6