Cellular localization of Y-box binding protein 1 in brain tissue of rats, macaques, and humans

Abstract

In conclusion, our study demonstrates that YB-1 is predominantly expressed in neurons in the adult brain of rats, macaques and humans. Lack of a co-localization with Glut-1 and P-glycoprotein argues against a direct role of YB-1 in the regulation of blood-brain barrier P-glycoprotein.

References

Page 1

	Year	Citations
Nuclear localization and increased levels of transcription factor YB-1 in primary human breast cancers are associated with intrinsic MDR1 gene expression Ralf C. Bargou, Karsten Jürchott, Christian Wagener, Nature Medicine Tumor BiologyRadiation OncologyBreast OncologyIncreased LevelsMedicine	1997	424
Seizure-Induced Up-Regulation of P-Glycoprotein at the Blood-Brain Barrier through Glutamate and Cyclooxygenase-2 Signaling Björn Bauer, Anika M. S. Hartz, Anton Pekcec, Molecular Pharmacology	2007	266
Direct Involvement of the Y-box Binding Protein YB-1 in Genotoxic Stress-induced Activation of the Human Multidrug Resistance 1 Gene Takefumi Ohga, Takeshi Uchiumi, Yoshinari Makino, Journal of Biological Chemistry	1998	235
The safety of interstitial chemotherapy with BCNU-loaded polymer followed by radiation therapy in the treatment of newly diagnosed malignant gliomas: Phase I trial Henry Brem, Matthew G. Ewend, Steven Piantadosi, Journal of Neuro-Oncology Neuro-oncologyRadiation TherapyMedicineInterstitial ChemotherapyBcnu-loaded Polymer	1995	207
Y‐box factor YB‐1 predicts drug resistance and patient outcome in breast cancer independent of clinically relevant tumor biologic factors HER2, uPA and PAI‐1 Martin Janz, Nadia Harbeck, P. Dettmar, International Journal of Cancer	2001	182
YB‐1 is upregulated during prostate cancer tumor progression and increases P‐glycoprotein activity Pepita Gimenez‐Bonafé, Matthew Fedoruk, Tanis G. Whitmore, The Prostate	2004	165
Structural organization of mRNA complexes with major core mRNP protein YB-1 Maxim A. Skabkin Nucleic Acids Research	2004	148
Hyperthermia-induced Nuclear Translocation of Transcription Factor YB-1 Leads to Enhanced Expression of Multidrug Resistance-related ABC Transporters Ulrike Stein, Karsten Jürchott, Wolfgang Walther, Journal of Biological Chemistry Molecular BiologyIncreased Mdr1Cancer BiologyTumor BiologyHyperthermia-induced Nuclear Translocation	2001	143
Nuclear expression of YB-1 protein correlates with P-glycoprotein expression in human osteosarcoma. Yoshinao Oda, Akio Sakamoto, Norio Shinohara, PubMed Nuclear ExpressionConventional OsteosarcomasP-glycoprotein ExpressionBreast OncologyMedicine	1998	130
Nuclear expression of Y‐box‐binding protein‐1 correlates with P‐glycoprotein and topoisomerase II alpha expression, and with poor prognosis in synovial sarcoma Yoshinao Oda, Yoshihiro Ohishi, Tsuyoshi Saito, The Journal of Pathology	2003	123

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