Concepedia

Cellular localization of Y-box binding protein 1 in brain tissue of rats, macaques, and humans

Bernadette Unkrüer, Anton Pekcec, Christina Fuest, Andrea Wehmeyer, María S. Balda, Anja K. E. Horn, Wolfgang Baumgärtner, Heidrun Potschka

BMC Neuroscience · 2009 · 23 citations · 24 references

DOIFull text

Open access

Abstract

In conclusion, our study demonstrates that YB-1 is predominantly expressed in neurons in the adult brain of rats, macaques and humans. Lack of a co-localization with Glut-1 and P-glycoprotein argues against a direct role of YB-1 in the regulation of blood-brain barrier P-glycoprotein.

References

24

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Ralf C. Bargou, Karsten Jürchott, Christian Wagener et al. · Nature Medicine · 1997 · 424 citations

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Seizure-Induced Up-Regulation of P-Glycoprotein at the Blood-Brain Barrier through Glutamate and Cyclooxygenase-2 Signaling

Björn Bauer, Anika M. S. Hartz, Anton Pekcec et al. · Molecular Pharmacology · 2007 · 266 citations

Direct Involvement of the Y-box Binding Protein YB-1 in Genotoxic Stress-induced Activation of the Human Multidrug Resistance 1 Gene

Takefumi Ohga, Takeshi Uchiumi, Yoshinari Makino et al. · Journal of Biological Chemistry · 1998 · 235 citations · Full text

The safety of interstitial chemotherapy with BCNU-loaded polymer followed by radiation therapy in the treatment of newly diagnosed malignant gliomas: Phase I trial

Henry Brem, Matthew G. Ewend, Steven Piantadosi et al. · Journal of Neuro-Oncology · 1995 · 207 citations

, , +10

Y‐box factor YB‐1 predicts drug resistance and patient outcome in breast cancer independent of clinically relevant tumor biologic factors HER2, uPA and PAI‐1

Martin Janz, Nadia Harbeck, P. Dettmar et al. · International Journal of Cancer · 2001 · 182 citations · Full text