Publication | Closed Access
Synthesis of Melatonin Receptor Agonist Ramelteon via Rh-catalyzed Asymmetric Hydrogenation of an Allylamine
22
Citations
18
References
2009
Year
Rhodium Josiphos ComplexMedicinal ChemistryEnantioselective SynthesisEngineeringBiochemistryMedicineKey PrecursorRh-catalyzed Asymmetric HydrogenationOrganic ChemistryOrganometallic CatalysisCatalysisAllylamine 1Stereoselective SynthesisPharmacologyAsymmetric CatalysisSynthetic ChemistryMelatoninBiomolecular Engineering
Abstract In the course of developing a practical synthetic method for the selective melatonin MT1/MT2 receptor agonist Ramelteon, a rhodium Josiphos complex was found to be an excellent catalyst for asymmetric hydrogenation of the key precursor, allylamine 1.
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