Concepedia

The Induction of Apoptosis by Local Anesthetics: A Comparison Between Lidocaine and Ropivacaine

Emmanuel Boselli, Fr d ric Duflo, Richard Debon, Bernard Allaouchiche, D. Chassard, L. Thomas, Jacques Portoukalian

Anesthesia & Analgesia · 2003 · 59 citations · 5 references

DOI

Abstract

This study suggests that lidocaine can induce apoptosis (detected by dual staining with Annexin V and propidium iodide) on T-cell line cultures in a time-dependent manner. This was not observed with ropivacaine.

References

5

A novel assay for apoptosis Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled Annexin V

I. Vermes, C. Haanen, H M Steffens-Nakken et al. · Journal of Immunological Methods · 1995 · 5.3K citations · Full text

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Comparison of the Effects of Bupivacaine and Ropivacaine on Heart Cell Mitochondrial Bioenergetics 

F. Sztark, Monique Malgat, P. Dabadie et al. · Anesthesiology · 1998 · 199 citations · Full text

Selective Direct Toxicity of Cocaine on Fetal Mouse Neurons: Teratogenic Implications of Neurite and Apoptotic Neuronal Loss

Marie‐Cécile Nassogne, Philippe Evrard, Pierre J. Courtoy · Annals of the New York Academy of Sciences · 1998 · 54 citations

The effect of the anaesthetic agent isoflurane on the rate of neutrophil apoptosisin vitro

Raymond Tyther, Noel Fanning, M. Halligan et al. · Irish Journal of Medical Science (1971 -) · 2001 · 38 citations

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Does chronic occupational exposure to volatile anesthetic agents influence the rate of neutrophil apoptosis?

Yukiko Goto, J. Gallagher, Noel Fanning et al. · Canadian Journal of Anesthesia/Journal canadien d anesthésie · 2000 · 26 citations · Full text

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