The vasoconstrictor action of big endothelin-1 is phosphoramidon-sensitive in rabbit saphenous artery, but not in saphenous vein

Pressor effects of circulating endothelin are limited by its removal in the pulmonary circulation and by the release of prostacyclin and endothelium-derived relaxing factor.

Gilberto De Nucci, Ranjeny Thomas, Pedro D’Orléans-Juste et al. · Proceedings of the National Academy of Sciences · 1988 · 1.4K citations · Full text

Endothelium-derived Relaxing Factor, Pulmonary Arterial Hypertension, Pulmonary Circulation +14

Venous smooth muscle contains vasoconstrictor ETB-like receptors

Suzanne Moreland, Diane M. McMullen, Carol L. Delaney et al. · Biochemical and Biophysical Research Communications · 1992 · 256 citations

Venous Disease, Molecular Physiology, Etb-like Receptors +6

Inhibition of biological actions of big endothelin-1 by phosphoramidon

Takahiro Fukuroda, Kazuhito Noguchi, Sonoko Tsuchida et al. · Biochemical and Biophysical Research Communications · 1990 · 146 citations

Signal Transduction, Molecular Physiology, Big Endothelin-1 +8

Conversion of big endothelin‐1 to endothelin‐1 by two types of metalloproteinases derived from porcine aortic endothelial cells

Yasuo Matsumura, Ruriko Ikegawa, Yaeko Tsukahara et al. · FEBS Letters · 1990 · 111 citations

Phosphoramidon inhibits the generation of endothelin‐1 from exogenously applied big endothelin‐1 in cultured vascular endothelial cells and smooth muscle cells

Ruriko Ikegawa, Yasuo Matsumura, Yaeko Tsukahara et al. · FEBS Letters · 1991 · 49 citations · Full text