Concepedia

B Lymphocyte Depletion with the Monoclonal Antibody Rituximab in Graves’ Disease: A Controlled Pilot Study

Daniel El Fassi, Claus Henrik Nielsen, Steen Joop Bonnema, Hans Carl Hasselbalch, Laszlo Hegedüs

The Journal of Clinical Endocrinology & Metabolism · 2007 · 153 citations · 9 references

DOIFull text

Open access

Abstract

RTX treatment may induce sustained remission in patients with GD with low TRAb levels. However, RTX did not affect autoantibody levels and seems ineffective in patients with high TRAb levels. At present, high cost, low efficacy, and potential side effects do not support use in uncomplicated GD.

References

9

The efficacy and safety of rituximab in patients with active rheumatoid arthritis despite methotrexate treatment: Results of a phase IIB randomized, double‐blind, placebo‐controlled, dose‐ranging trial

Paul Emery, Roy Fleischmann, Anna Filipowicz‐Sosnowska et al. · Arthritis & Rheumatism · 2006 · 1K citations

Reconstitution of peripheral blood B cells after depletion with rituximab in patients with rheumatoid arthritis

Maria Leandro, Geraldine Cambridge, Michael R. Ehrenstein et al. · Arthritis & Rheumatism · 2006 · 549 citations

The Determination of Thyroid Volume by Ultrasound and Its Relationship to Body Weight, Age, and Sex in Normal Subjects

László Hegedüs, Hans Perrild, Lars Rytter Poulsen et al. · The Journal of Clinical Endocrinology & Metabolism · 1983 · 365 citations

Efficacy of rituximab treatment for thyroid-associated ophthalmopathy as a result of intraorbital B-cell depletion in one patient unresponsive to steroid immunosuppression

Mario Salvi, Guia Vannucchi, Irene Campi et al. · European Journal of Endocrinology · 2006 · 146 citations · Full text

, , +15

Serum Thyrotropin Receptor Antibodies Concentrations in Patients with Graves' Disease Before, at the End of Methimazole Treatment, and After Drug Withdrawal: Evidence That the Activity of Thyrotropin Receptor Antibody and/or Thyroid Response Modify During the Observation Period

Carlo Carella, Gherardo Mazziotti, F. Sorvillo et al. · Thyroid · 2006 · 117 citations