Phosphorylation of Both Phosphoacceptor Sites in the HIV-1 Vpu Cytoplasmic Domain Is Essential for Vpu-Mediated ER Degradation of CD4

Site-directed mutagenesis by overlap extension using the polymerase chain reaction

Steffan N. Ho, Henry D. Hunt, Robert M. Horton et al. · Gene · 1989 · 7.5K citations

Natural Sciences, Genetics, Directed Evolution +6

The CD4 (T4) antigen is an essential component of the receptor for the AIDS retrovirus

Angus Dalgleish, Peter C. L. Beverley, Paul R. Clapham et al. · Nature · 1984 · 3.5K citations · Full text

Human Retrovirus, Immunology, Antiviral Response +8

T-lymphocyte T4 molecule behaves as the receptor for human retrovirus LAV

David Klatzmann, Éric Champagne, S. Chamaret et al. · Nature · 1984 · 2.4K citations

Viral Persistence, Human Retrovirus, Immunology +9

Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells

Sally A. Cowley · Cell · 1994 · 2K citations

Nih 3T3, Developmental Biology, Signal Transduction +11

Human immunodeficiency virus type 1 Vpu protein induces rapid degradation of CD4

R L Willey, Frank Maldarelli, María Ángeles Martín et al. · Journal of Virology · 1992 · 546 citations · Full text

Viral Replication, Human Retrovirus, Pathogenesis +13