GRANULOMA INGUINALE OF THE VAGINA AND CERVIX UTERI WITH BONE METASTASES

Abstract

Since McLeod's description in 1882 of granuloma inguinale as a "serpiginous or lupoid ulceration of the genitalia," this disease has been more clearly differentiated from other granulomatous lesions of the genitalia and the vagaries of its clinical manifestations have received increasing attention. Earlier concepts of the progress of this infection solely by serpiginous spread or by autoinoculation have been broadened in recent years as a result of accumulated evidence of lymphatic spread and involvement.¹Examples of the latter are the inguinal "pseudobubo"^1afollowing the primary genital lesion, the demonstration of the Donovan bodies in regional lymph nodes^1a,band the elephantiasis of the genitalia²which may occur in this disease. To lymphatic spread has also been attributed the extensive involvement of the pelvic organs following granuloma inguinale of the cervix and vagina.³Of significance are the pronounced systemic manifestations which are frequently associated with lesions in