Science · 1977 · 31 citations · 8 references
Glomerular DiseaseRenal PathologyImmunologyPathologySurgerySham-operated ControlsGlomerulonephritisRenal FunctionKidney Tubule RemodelingChronic Kidney DiseaseAutoimmune DiseaseKidney FailureAutoimmunityRenal PathophysiologyNzb/nzw MiceUrologyRenal DiseaseSingle KidneyMedicineNephrologyKidney ResearchSame Age
Male F1 New Zealand Black X New Zealand White mice, which spontaneously develop immune complex renal disease, underwent unilateral nephrectomy at 3 months of age and were compared with sham-operated controls. At 12 months of age only 24% of mice with a single kidney were alive, while 85% of sham-operated controls survived to the same age. Unilaterally nephrectomized mice had more severe renal histologic changes, as shown by light and immunofluorescence microscopy.
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