Hyperosmolar Saline Is a Proinflammatory Stress on the Mouse Ocular Surface

Abstract

These results show that the hyperosmolarity stimulates expression and production of IL-1beta, TNF-alpha, and MMP-9 and activates JNK, ERK, and p38 MAPK signaling pathways on the mouse ocular surface. These findings suggest that hyperosmolar stress, as it may occur in dry eye, promotes ocular surface inflammation.

References

Page 1

	Year	Citations
Matrix metalloproteinases and their inhibitors in connective tissue remodeling J. Frederick Woessner The FASEB Journal	1991	3.3K
The stress-activated protein kinase subfamily of c-Jun kinases John Kyriakis, Papia T. Banerjee, Eleni Nikolakaki, Nature C-jun KinasesSignal TransductionSignaling PathwayCell RegulationReceptor Tyrosine Kinase	1994	2.6K
Pro-inflammatory Cytokines and Environmental Stress Cause p38 Mitogen-activated Protein Kinase Activation by Dual Phosphorylation on Tyrosine and Threonine Joël Raingeaud, Shashi Kumar Gupta, Jeffrey S. Rogers, Journal of Biological Chemistry	1995	2.2K
Selective interaction of JNK protein kinase isoforms with transcription factors. Shreyasi Gupta, Tyler W. Barrett, Alan J. Whitmarsh, The EMBO Journal Transcriptional RegulationSignal TransductionSignaling PathwayMolecular RegulationNatural Sciences	1996	1.3K
Ultraviolet Light and Osmotic Stress: Activation of the JNK Cascade Through Multiple Growth Factor and Cytokine Receptors Caridad Rosette, Michael Karin Science Ultraviolet LightImmunologyDermatologyCell GrowthCellular Physiology	1996	1K
Effects of Matrix Metalloproteinase-9 Gene Knock-Out on the Proteolysis of Blood–Brain Barrier and White Matter Components after Cerebral Ischemia Minoru Asahi, Xiaoying Wang, Tatsuro Mori, Journal of Neuroscience	2001	996
Pro- and anti-inflammatory forms of interleukin-1 in the tear fluid and conjunctiva of patients with dry-eye disease. Abraham Solomon, Dilek Dursun, Zhihong Liu, PubMed	2001	729
Altered cytokine balance in the tear fluid and conjunctiva of patients with Sjögren's syndrome keratoconjunctivitis sicca Stephen C. Pflugfelder, David Jones, Zhonghua Ji, Current Eye Research	1999	608
An Osmosensing Signal Transduction Pathway in Mammalian Cells Zoya Galcheva-Gargova, Benoît Dérijard, I‐Huan Wu, Science Mammalian Protein KinaseEngineeringCytoskeletonCellular PhysiologyHuman Jnk	1994	574
Oxidative Stress-Induced Actin Reorganization Mediated by the p38 Mitogen-Activated Protein Kinase/Heat Shock Protein 27 Pathway in Vascular Endothelial Cells Jacques Huot, François Houle, François Marceau, Circulation Research	1997	567

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