Steroide und Sexualhormone 242. Mitteilung [1] herstellung von 14β‐hydroxy‐20‐keto‐δ¹⁶‐steroiden: Ein neuer ergiebiger zugang zu 3‐O‐methyl‐17α, 20ξ‐tetrahydrobatrachotoxinin A

Abstract

Abstract A novel method for the reductive epoxide opening in a 14β, 15β‐epoxy‐20‐oxo‐Δ 16 ‐pregnene 4 affords an almost quantitative yield of the 14β‐hydroxy‐20‐oxo‐Δ 16 ‐pregnene 5. This leads to a considerable improvement of the formerly published synthesis of 3‐O‐methyl 17 α, 20ξ‐tetrahydrobatrachotoxinin A ( 2 ) [3].