Amphiphilic Dendrimers: Novel Self‐Assembling Vectors for Efficient Gene Delivery

Abstract

A sharp maximum in the structure–activity relationship, a surprisingly strong influence of the hydrophobic part on DNA binding and transport, and an unusual serum effect on relative transfection activities were found in preliminary biological data on a series of four amphiphilic dendrimers designed as transfection agents. The lowest generation dendrimer 1 was found to be the most active.