Apoptosis induced by a new flavonoid in human hepatoma HepG2 cells involves reactive oxygen species-mediated mitochondrial dysfunction and MAPK activation

Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis

Donald W. Nicholson, Ambereen Ali, Nancy A. Thornberry et al. · Nature · 1995 · 4K citations

Protein Function, Biochemistry, Ice/ced-3 Protease +11

Caspase-3 Activation is a Critical Determinant of Genotoxic Stress-Induced Apoptosis

Suparna Mazumder, Dragos Plesca, Alexandru Almasan · Humana Press eBooks · 2008 · 361 citations

Immunocytochemical Technique, Apoptosis, Immunology +20

Emodin induces apoptosis in human lung adenocarcinoma cells through a reactive oxygen species-dependent mitochondrial signaling pathway

Yuting Su, Huei-Ling Chang, Song‐Kun Shyue et al. · Biochemical Pharmacology · 2005 · 246 citations

Mitochondrial Function, Medicine, Lipid Peroxidation +13

Free radicals: From basic science to medicine

Giuseppe Poli, Emanuele Albano, Umberto Dianzani · Free Radical Biology and Medicine · 1994 · 173 citations

Medicine, Radical (Chemistry), Lipid Peroxidation +6

Induction apoptosis of luteolin in human hepatoma HepG2 cells involving mitochondria translocation of Bax/Bak and activation of JNK

Herng-Jiun Lee, Chau‐Jong Wang, Hsing‐Chun Kuo et al. · Toxicology and Applied Pharmacology · 2004 · 168 citations

Induction Apoptosis, Mitophagy, Biochemistry +10