Apigenin inhibits the production of NO and PGE2 in microglia and inhibits neuronal cell death in a middle cerebral artery occlusion-induced focal ischemia mice model

Evaluation of 2,3,5-triphenyltetrazolium chloride as a stain for detection and quantification of experimental cerebral infarction in rats.

Joshua B. Bederson, L H Pitts, Isabelle M. Germano et al. · Stroke · 1986 · 1.3K citations · Full text

Life Sciences, Neurobiology, Neuroscience +14

Blockade of Microglial Activation Is Neuroprotective in the 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine Mouse Model of Parkinson Disease

Du Chu Wu, Vernice Jackson‐Lewis, Miquel Vila et al. · Journal of Neuroscience · 2002 · 1.2K citations · Full text

Life Sciences, Neurobiology, Neuroscience +17

Activated microglia mediate neuronal cell injury via a nitric oxide mechanism

C C Chao, S Hu, Thomas W. Molitor et al. · The Journal of Immunology · 1992 · 1.1K citations

Life Sciences, Neurobiology, Neuroscience +14

A tetracycline derivative, minocycline, reduces inflammation and protects against focal cerebral ischemia with a wide therapeutic window

Juha Yrjänheikki, Tiina Tikka, Riitta Keinänen et al. · Proceedings of the National Academy of Sciences · 1999 · 1K citations

Life Sciences, Neuroscience, Pharmacology +17

Tetracyclines inhibit microglial activation and are neuroprotective in global brain ischemia

Juha Yrjänheikki, Riitta Keinänen, M. Pellikka et al. · Proceedings of the National Academy of Sciences · 1998 · 996 citations

Medicine, Pharmacology, Molecular Neurobiology +12