Concepedia

A<sub>2A</sub>-Adenosine Receptor Reserve for Coronary Vasodilation

John C. Shryock, Stephen Snowdy, Pier Giovanni Baraldi, Barbara Cacciari, Giampiero Spalluto, Angela Monopoli, Ennio Ongini, Stephen P. Baker, Luiz Belardinelli

Circulation · 1998 · 187 citations · 22 references

DOI

Abstract

Receptor reserves for 3 A2A-AdoR agonists were large. The receptor reserve for A2A-AdoRs to cause an increase of coronary conductance can explain both the high potency of adenosine to cause coronary vasodilation and the observation that an A2A-AdoR agonist can cause coronary vasodilation without systemic effects.

References

22

Pharmacologic Analysis of Drug Receptor Interaction

Kenakin. T. Kenakin · Therapeutic Drug Monitoring · 1988 · 929 citations

, , +11

COMPARISON OF DISSOCIATION CONSTANTS AND OF RELATIVE EFFICACIES OF SELECTED AGONISTS ACTING ON PARASYMPATHETIC RECEPTORS*

Robert F. Furchgott, Paula Bursztyn · Annals of the New York Academy of Sciences · 1967 · 527 citations

, , +7

Subclasses of adenosine receptors in the central nervous system: Interaction with caffeine and related methylxanthines

John W. Daly, Pamela Butts-Lamb, William L. Padgett · Cellular and Molecular Neurobiology · 1983 · 443 citations · Full text

, , +11

The in vitro pharmacology of ZM 241385, a potent, non‐xanthine, A<sub>2a</sub>selective adenosine receptor antagonist

Simon M. Poucher, J R Keddie, Parminder Singh et al. · British Journal of Pharmacology · 1995 · 362 citations · Full text

CGS 21680C, an A2 selective adenosine receptor agonist with preferential hypotensive activity.

A. Hutchison, Randy L. Webb, H H Oei et al. · Journal of Pharmacology and Experimental Therapeutics · 1989 · 245 citations · Full text