A<sub>2A</sub>-Adenosine Receptor Reserve for Coronary Vasodilation

Abstract

Receptor reserves for 3 A2A-AdoR agonists were large. The receptor reserve for A2A-AdoRs to cause an increase of coronary conductance can explain both the high potency of adenosine to cause coronary vasodilation and the observation that an A2A-AdoR agonist can cause coronary vasodilation without systemic effects.

References

Page 1

	Year	Citations
Pharmacologic Analysis of Drug Receptor Interaction Kenakin. T. Kenakin Therapeutic Drug Monitoring Data AffinityDrug InteractionsDrug Receptor InteractionDrug TargetReceptor Classification Kinetics	1988	929
COMPARISON OF DISSOCIATION CONSTANTS AND OF RELATIVE EFFICACIES OF SELECTED AGONISTS ACTING ON PARASYMPATHETIC RECEPTORS* Robert F. Furchgott, Paula Bursztyn Annals of the New York Academy of Sciences NeurophysiologyMedicineFunctional SelectivityPhysiologyNeuropeptide Receptor	1967	527
Subclasses of adenosine receptors in the central nervous system: Interaction with caffeine and related methylxanthines John W. Daly, Pamela Butts-Lamb, William L. Padgett Cellular and Molecular Neurobiology Adenosine ReceptorsNeurophysiologyMedicinePhysiologyAnesthetic Mechanism	1983	443
The in vitro pharmacology of ZM 241385, a potent, non‐xanthine, A<sub>2a</sub>selective adenosine receptor antagonist Simon M. Poucher, J R Keddie, Parminder Singh, British Journal of Pharmacology	1995	362
CGS 21680C, an A2 selective adenosine receptor agonist with preferential hypotensive activity. A. Hutchison, Randy L. Webb, H H Oei, Journal of Pharmacology and Experimental Therapeutics	1989	245
Release of adenosine, inosine and hypoxanthine from the isolated guinea pig heart during hypoxia, flow-autoregulation and reactive hyperemia J�rgen Schrader, Francis J. Haddy, E. Gerlach Pflügers Archiv - European Journal of Physiology Cardiogenic ShockPhysiologyHypoxia (Medicine)AnesthesiologyTissue Oxygenation	1977	199
The non-xanthine heterocyclic compound SCH 58261 is a new potent and selective A2a adenosine receptor antagonist. Cristina Zocchi, E. Ongini, Andrea Conti, Journal of Pharmacology and Experimental Therapeutics	1996	197
The A2A Adenosine Receptor Mediates Coronary Vasodilation Luiz Belardinelli, John C. Shryock, Stephen Snowdy, Journal of Pharmacology and Experimental Therapeutics	1998	179
Ligand selectivity of dog coronary adenosine receptor resembles that of adenylate cyclase stimulatory (Ra) receptors. Shozo Kusachi, R. Thompson, R A Olsson Journal of Pharmacology and Experimental Therapeutics	1983	109
An isolated guinea pig heart preparation with in vivo like features Rolf B�nger, Francis J. Haddy, Axel Quereng�sser, Pflügers Archiv - European Journal of Physiology Cardiac MuscleStructural Heart DiseasePhysiologyElectrophysiologyCardiovascular Physiology	1975	109

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