Concepedia

An improved synthesis of galanthamine

Jerzy Szewczyk, Anita H. Lewin, F. Ivy Carroll

Journal of Heterocyclic Chemistry · 1988 · 38 citations · 3 references

DOI

Concepts

Abstract

Abstract Modifications in the total synthesis of the Amarylidaceae alkaloid of galanthamine from commercially available isovanillin and tyramine have resulted in a shortened reaction sequence, which is amenable to upscaling and in improved product yield.

References

3

Stereochemical studies. LIV. A biogenetic-type asymmetric synthesis of optically active galanthamine from L-tyrosine.

Kimihiro Shimizu, Kiyoshi Tomioka, Shun‐ichi Yamada et al. · Chemical and Pharmaceutical Bulletin · 1978 · 46 citations · Full text

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Studies on the syntheses of heterocyclic compounds. Part CCCXV. Modified total synthesis of (±)-galanthamine through phenol oxidation

T. KAMETANI, K. YAMAKI, H. Yagi et al. · Journal of the Chemical Society C Organic · 1969 · 39 citations

, , +10

Studies on the syntheses of heterocyclic compounds. Part CCCLXXXVI. Alternative total syntheses of galanthamine and N-benzylgalanthamine iodide

Tetsuji Kametani, C. Seino, K. YAMAKI et al. · Journal of the Chemical Society C Organic · 1971 · 25 citations

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