Journal of the Chemical Society C Organic · 1971 · 25 citations · 0 references
Natural SciencesChemistryMedicinal ChemistryOrganic ChemistryStructure-activity RelationshipsSynthetic Medicinal ChemistryAnalgesic PharmacologyHeterocycle SynthesisHeterocyclic ChemistryHeterocyclic CompoundsOpioid AnalgesicsOrganic SynthesisBioactive HeterocyclesHeterocyclic Medicinal ChemistryMedicinal Chemistry ApplicationsMedicinal HeterocyclesOxidative Coupling Reactions
Alternative total syntheses of galanthamine (Ia) and N-benzylgalanthamine iodide (VIa) were carried out by phenolic oxidative reactions of the corresponding amides (IIIf and e). Both (–)-and (±)-galanthamine showed analgesic activity comparable to that of morphine.