Human Polymorphonuclear Neutrophils are Recruited by Porcine Chemokines Acting on CXC Chemokine Receptor 2, and Platelet-Activating Factor

Abstract

Both chemokines acting via CXCR2 and PAF are released by porcine EC inducing efficient chemotaxis of human PMN. These mechanisms responsible for the recruitment of human PMN to porcine endothelium during cell-mediated rejection of xenografts represent potential targets for preventive strategies.