The Effects of Volatile General Anesthetics on Adenosine Diphosphate-induced Platelet Aggregation

Abstract

Platelet aggregation induced by ADP in canine platelet-rich plasma was inhibited by volatile anesthetics. The partial pressures at which platelet aggregation was inhibited 50 per cent correlated closely with the pressures used clinically: methoxyflurane, 3.5 torr; halothane, 7.5 torr; diethyl ether,