Polypoid and junctional squamous cell carcinoma of the tongue and larynx with spindle cell carcinoma (“PSEUDOSARCOMA”)

Abstract

T plied to 2 types of lesions.One of these, pseudosarcomatous fibromatosis or nodular fasciitis,* is clearly a connective tissue proliferation; it is unassociated with squamous carcinoma and is not within the scope of this discussion.The other type has a spindle cell proliferation that is related to squamous or epidermoid carcinoma.In this latter group are the pseudosarcomas of the larynx,4 spindle cell carcinomas,2$ 6, 9 and some carcinosarcomas.6The origin of the spindle cells and their malignancy have not been clearly established, in most cases resulting in considerable controversy on the subject.Recent reports on pseudosarcoma of the larynx1.3 have supported Lane's concept4 of a noncancerous basis for the spindle ceIl proliferation.Three cases of polypoid pseudosarcomatous carcinoma, 2 of the tongue and 1 of the larynx, are reported because they add considerable support to the neoplastic concept of pseudosarcoma.The epithelial spindle cell proliferation that was demonstrated was found to be associated with 2 phenomena, junctional epithelial activity and a tissue culture type proliferation of squamous cells. CASE REPORTSCase 1.A 56-year-old white man was first seen on June 1, 1961.He had brought with him a smooth and roughly oval, soft tissue nodule about l c m in diameter, which he had coughed up the previous day.The mass was reported by the pathologist as a "myxomatous polyp and pseudosarcoma" with a note re-