Identification of 4-hydroxyquinolines inhibitors of p300/CBP histone acetyltransferases

Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer

Mario F. Fraga, Esteban Ballestar, Ana Villar‐Garea et al. · Nature Genetics · 2005 · 1.9K citations

Life Sciences, Cancer Biology, Molecular Biology +13

Curcumin, a Novel p300/CREB-binding Protein-specific Inhibitor of Acetyltransferase, Represses the Acetylation of Histone/Nonhistone Proteins and Histone Acetyltransferase-dependent Chromatin Transcription

Karanam Balasubramanyam, Radhika A. Varier, Mohammad Altaf et al. · Journal of Biological Chemistry · 2004 · 819 citations · Full text

Life Sciences, Molecular Biology, Pharmacology +14

Mutations truncating the EP300 acetylase in human cancers

Simon A. Gayther, Sarah J. Batley, Lori Linger et al. · Nature Genetics · 2000 · 593 citations

Life Sciences, Genetics, Molecular Biology +12

Polyisoprenylated Benzophenone, Garcinol, a Natural Histone Acetyltransferase Inhibitor, Represses Chromatin Transcription and Alters Global Gene Expression

Karanam Balasubramanyam, Mohammad Altaf, Radhika A. Varier et al. · Journal of Biological Chemistry · 2004 · 547 citations · Full text

Medicine, Molecular Biology, Pharmacology +16

Small Molecule Modulators of Histone Acetyltransferase p300

Karanam Balasubramanyam, Anupama Ranganathan, Tapas K. Kundu · Journal of Biological Chemistry · 2003 · 511 citations · Full text

Life Sciences, Molecular Biology, Pharmacology +15