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Repair Excision of Alkylated Bases from DNA <i>in vivo</i>
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1976
Year
ChromatinGenome InstabilityOrgan SpecificityDna DamageGenome SurgeryOncogenic AgentRepair ExcisionNatural SciencesMolecular BiologyDna ReplicationCarcinogenic EffectNuclear DnaMedicineRadiation OncologyEpigeneticsNuclear MedicineMutagenesis
Recent experiments are reviewed which indicate that O6-alkylation of guanine in nuclear DNA constitutes a promutagenic lesion possibly implicated in malignant transformation by monofunctional alkylating carcinogens. The differential capacity of various organs to enzymically excise O6-alkylguanine from their DNA seems to correlate with the organ specificity of the carcinogenic effect.