Susceptibility of brain microvascular endothelial cells to advanced glycation end products-induced tissue factor upregulation is associated with intracellular reactive oxygen species

Activation of NADPH oxidase by AGE links oxidant stress to altered gene expression via RAGE

Marie‐Paule Wautier, Olivier Chappey, Stefano Corda et al. · American Journal of Physiology-Endocrinology and Metabolism · 2001 · 1.1K citations

Life Sciences, Biochemistry, Cell Biology +17

Advanced glycation endproducts interacting with their endothelial receptor induce expression of vascular cell adhesion molecule-1 (VCAM-1) in cultured human endothelial cells and in mice. A potential mechanism for the accelerated vasculopathy of diabetes.

A.M. Schmidt, Osamu Hori, J X Chen et al. · Journal of Clinical Investigation · 1995 · 896 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +15

Advanced Glycation End Products Activate Endothelium Through Signal-Transduction Receptor RAGE

Giuseppina Basta, Guido Lazzerini, Marika Massaro et al. · Circulation · 2002 · 541 citations

Life Sciences, Cell Biology, Immunology +17

Protective effects of MCI-186 on cerebral ischemia: possible involvement of free radical scavenging and antioxidant actions.

Toshiaki Watanabe, Satoshi Yuki, Mariko Egawa et al. · Journal of Pharmacology and Experimental Therapeutics · 1994 · 464 citations

Medicine, Neuroscience, Pharmacology +17

Stroke in patients with diabetes. The Copenhagen Stroke Study.

Henrik Jørgensen, Hirofumi Nakayama, Hans Otto Raaschou et al. · Stroke · 1994 · 386 citations · Full text

Medicine, Internal Medicine, Neurology +16