Concepedia

Palladated and platinated complexes derived from phenylacetaldehyde thiosemicarbazone with cytotoxic activity in cis-DDP resistant tumor cells. Formation of DNA interstrand cross-links by these complexes

Adoración G. Quiroga, José M. Pérez, Eva I. Montero, José R. Masaguer, Carlos Alonso, Carmen Navarro‐Ranninger

Journal of Inorganic Biochemistry · 1998 · 68 citations · 27 references

Concepts

MedicineMedicinal ChemistryOncologyCancer PharmacologyChemotherapyMolecular OncologyChemotherapy ResistanceCytotoxic ChemotherapyDna ChemistryDna CrosslinkingOrganometallic Anticancer AgentsPlatinum CompoundsPlatinum-based AgentsPlatinum-induced Dna Crosslinks

References

27

Feasibility of drug screening with panels of human tumor cell lines using a microculture tetrazolium assay.

Michael C. Alley, Dominic A. Scudiero, Anne Monks et al. · PubMed · 1988 · 3.1K citations

Medicine, Oncology, Pharmacology +14

Transition metal complexes of semicarbazones and thiosemicarbazones

Subhash Padhyé, George B. Kauffman · Coordination Chemistry Reviews · 1985 · 781 citations

Natural Sciences, Chemistry, Medicinal Chemistry +12

The Mechanism of Action of Antitumor Platinum Compounds

J. J. Roberts, Andrew J. Thomson · Progress in nucleic acid research and molecular biology · 1979 · 410 citations

Medicine, Medicinal Chemistry, Oncology +12

Transition metal complexes in cancer chemotherapy

M. J. Cleare · Coordination Chemistry Reviews · 1974 · 319 citations

Natural Sciences, Chemistry, Oncology +14

The relevance of hydrogen bonding in the mechanism of action of platinum antitumor compounds

J. Reedijk · Inorganica Chimica Acta · 1992 · 247 citations

Natural Sciences, Chemistry, Medicinal Chemistry +14