Journal of Natural Products · 2011 · 130 citations · 19 references
PharmacyMedicinal ChemistryMicrobiologyBioorganic ChemistryDrug DiscoverySynthetic Medicinal ChemistryAntibacterial AgentsMarine Bioactive CompoundsMarine Drug DiscoveryAntimicrobial Marine CompoundsBioactive Compounds From Marine FungiBioactive Marine MetabolitesEscherichia ColiMarine Actinomycetes As Drug SourcesMarine AlkaloidsMarine Microbial Natural ProductsMarine-derived Antimicrobial Compounds
Five new bipyridine alkaloids (1-5) and a new phenylpyridine alkaloid (6), which we name caerulomycins F-K, along with five known analogues (7-11), were isolated from the marine-derived actinomycete Actinoalloteichus cyanogriseus WH1-2216-6. The structures of 1-6 were established on the basis of spectroscopic analyses and chemical methods. Compounds 1-10 showed cytotoxicity against the HL-60, K562, KB, and A549 cell lines, with IC₅₀ values of 0.26 to 15.7 μM. Compounds 7 and 8 also showed antimicrobial activities against Escherichia coli, Aerobacter aerogenes, Pseudomonas aeruginosa, and Candida albicans, with MIC values of 9.7 to 38.6 μM.
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New Colorimetric Cytotoxicity Assay for Anticancer-Drug Screening
Philip Skehan, Ritsa Storeng, Dominic A. Scudiero et al. · JNCI Journal of the National Cancer Institute · 1990 · 9.8K citations
Medicine, Oncology, Pharmacology +10
John W. Blunt, Brent R. Copp, Murray H. G. Munro et al. · Natural Product Reports · 2010 · 407 citations · Full text