Synthesis and .ALPHA.-glucosidase-inhibiting activity of a new .ALPHA.-glucosidase inhibitor, 4-O-.ALPHA.-D-glucopyranosylmoranoline and its N-substituted derivatives.

Abstract

Various N-substituted derivatives of 4-O-alpha-D-glucopyranosylmoranoline have been synthesized, and their inhibitory activities against rabbit sucrase and maltase have been measured, as well as their effects on postprandial hyperglycemia in the sucrose-loaded rat, 4-O-alpha-D-Glucopyranosylmoranoline was also shown to have potent hypoglycemic activity in starch-loaded dogs.