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Synthesis and .ALPHA.-glucosidase-inhibiting activity of a new .ALPHA.-glucosidase inhibitor, 4-O-.ALPHA.-D-glucopyranosylmoranoline and its N-substituted derivatives.
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1989
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Pharmaceutical ScienceBioorganic ChemistryGlycobiologySucrose-loaded RatNew .Alpha.-glucosidase InhibitorPharmacotherapyPharmaceutical ChemistryRabbit SucraseMedicinal ChemistryPharmacological Study.Alpha.-glucosidase-inhibiting ActivityInhibitory ActivityGlycosylationBiochemistryDrug DevelopmentPharmacologyN-substituted DerivativesNatural SciencesPhysiologyVarious N-substituted DerivativesMedicineDrug Discovery
Various N-substituted derivatives of 4-O-alpha-D-glucopyranosylmoranoline have been synthesized, and their inhibitory activities against rabbit sucrase and maltase have been measured, as well as their effects on postprandial hyperglycemia in the sucrose-loaded rat, 4-O-alpha-D-Glucopyranosylmoranoline was also shown to have potent hypoglycemic activity in starch-loaded dogs.