Functional Screening of G Protein–Coupled Receptors by Measuring Intracellular Calcium with a Fluorescence Microplate Reader

The Sequence of the Human Genome

J. Craig Venter, Mark D. Adams, Eugene W. Myers et al. · Science · 2001 · 13.7K citations

Life Sciences, Genetics, Molecular Genetics +11

Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

Yung-Chi Cheng, William H. Prusoff · Biochemical Pharmacology · 1973 · 12.9K citations

Life Sciences, Biochemistry, Chemical Kinetics +14

Lithium amplifies agonist-dependent phosphatidylinositol responses in brain and salivary glands

Michael J. Berridge, C. Peter Downes, Michael R. Hanley · Biochemical Journal · 1982 · 2.1K citations · Full text

Medicine, Biochemistry, Pharmacology +12

Antagonist binding profiles of five cloned human muscarinic receptor subtypes.

Frank Dörje, J. Wess, G. Lambrecht et al. · Journal of Pharmacology and Experimental Therapeutics · 1990 · 612 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +13

Radioimmunoassay of cyclic AMP and cyclic GMP.

Gary Brooker, Harper Jf, Terasaki Wl et al. · PubMed · 1979 · 555 citations

Life Sciences, Biochemistry, Immunology +8