Gynecologic and Obstetric Investigation · 2002 · 62 citations · 15 references
Life SciencesGeneticsMolecular GeneticsHigh-risk PregnancyHuman GeneticsMedical GeneticsEclampsiaGenetic DisordersGenetic Risk FactorsHypertensive DisordersFactor V Leiden ThrombophiliaMendelian Risk FactorsMethylenetetrahydrofolate Reductase PolymorphismsPreeclampsia PathophysiologyProthrombin G20210a MutationProthrombin Gene MutationSubjectsThrombophilia In Pregnancy
BACKGROUND: The association between thrombophilic variants (Leiden mutation of the factor V gene, G20210A mutation of the prothrombin gene and C677T polymorphism of the methylenetetrahydrofolate reductase (MTHFR) gene) with preeclampsia was investigated in a north-eastern Italian population. METHODS: Fifty-eight preeclamptic (PE) women and 74 normal pregnancies were evaluated. Genotypes were determined by polymerase chain reaction. RESULTS: The frequency of heterozygous carriers of the factor V Leiden was similar between PE women (5.2%) compared to the control subjects (4.1%; p 0.76). Also the frequencies of G20210A and C677T mutations were similar between PE and control subjects. CONCLUSIONS: In this population, we found no difference in the prevalence of genetic risk factors for thrombosis in women with preeclampsia compared with control subjects.
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