Chemical Communications · 2013 · 39 citations · 25 references
Natural SciencesChemistryMedicinal ChemistryOrganic ChemistryOrganometallic ChemistrySynthetic Medicinal ChemistryMacrocycle SynthesisAllylic FunctionalizationAllylic SubstitutionMetal-templated SynthesisPyridine ChemistryPyridine Synthesis
IBX facilitated the reaction of β-enamino esters with allylic alcohols affording a direct, one-pot and metal free synthesis of functionalized pyridines including 2-substituted nicotinic acids, densely substituted pyridines and precursors of azafluorenones. The methodology also afforded the racemic pyridine core of cyclothiazomycin.
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