Identification of transgene integration loci of different highly expressing recombinant CHO cell lines by FISH

Isolation of Chinese hamster cell mutants deficient in dihydrofolate reductase activity.

G Urlaub, Lawrence A. Chasin · Proceedings of the National Academy of Sciences · 1980 · 910 citations

Life Sciences, Genetics, Molecular Genetics +9

Recombinase-Mediated Gene Activation and Site-Specific Integration in Mammalian Cells

Stephen O’Gorman, Daniel T. Fox, Geoffrey M. Wahl · Science · 1991 · 579 citations

Medicine, Genetics, Molecular Genetics +17

Genetics of somatic mammalian cells, VII. Induction and isolation of nutritional mutants in Chinese hamster cells.

Fa‐Ten Kao, Theodore T. Puck · Proceedings of the National Academy of Sciences · 1968 · 461 citations · Full text

Life Sciences, Genetics, Neuroscience +17

Amplified dihydrofolate reductase genes in unstably methotrexate-resistant cells are associated with double minute chromosomes.

Randal J. Kaufman, Peter C. Brown, Robert Schimke · Proceedings of the National Academy of Sciences · 1979 · 398 citations · Full text

Life Sciences, Genetics, Molecular Genetics +11

Amplified dihydrofolate reductase genes are localized to a homogeneously staining region of a single chromosome in a methotrexate-resistant Chinese hamster ovary cell line.

Jack H. Nunberg, Randal J. Kaufman, Robert Schimke et al. · Proceedings of the National Academy of Sciences · 1978 · 394 citations · Full text

Life Sciences, Genetics, Molecular Genetics +12