Antimicrobial Agents and Chemotherapy · 2014 · 15 citations · 27 references
PharmacyMedicinal ChemistryPharmacologyDrug DesignDrug DiscoverySynthetic Medicinal ChemistryAnthelmintic PharmacologyAntiparasitic AgentsAntiparasitic ChemotherapyAntiparasitic PharmacologyAntiparasitic TherapyParasite PreventionBiological Activity FeaturesSubstituent Effects On Biological ActivityTreatment Of TrypanosomiasisTrypanosoma Cruzi InfectionTrypanosomatid-host InteractionsTrypanosome Infections
Fifteen novel arylimidamides (AIAs) (6 bis-amidino and 9 mono-amidino analogues) were assayed against Trypanosoma cruzi in vitro and in vivo. All the bis-AIAs were more effective than the mono-AIAs, and two analogues, DB1967 and DB1989, were further evaluated in vivo. Although both of them reduced parasitemia, protection against mortality was not achieved. Our results show that the number of amidino-terminal units affects the efficacy of arylimidamides against T. cruzi.
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M. Z. L. Meirelles, Tânia Cremonini de Araújo-Jorge, Christina Miranda et al. · PubMed · 1986 · 152 citations