New concepts in the modulation of leukotriene synthesis

Leukotriene B, a potent chemokinetic and aggregating substance released from polymorphonuclear leukocytes

A. W. Ford‐Hutchinson, M.A. Bray, Mira Doig et al. · Nature · 1980 · 2.1K citations

Inflammation, Cytokine, Granulocyte +10

Leukotrienes are potent constrictors of human bronchi

Sven‐Erik Dahlén, Per Hedqvist, Sven Hammarström et al. · Nature · 1980 · 969 citations

Inflammation, Inflammatory Lung Disease, Lung Inflammation +5

Transformation of arachidonic acid by rabbit polymorphonuclear leukocytes. Formation of a novel dihydroxyeicosatetraenoic acid.

P Borgeat, Bengt Samuelsson · Journal of Biological Chemistry · 1979 · 653 citations · Full text

Biosynthesis, Biochemistry, Granulocyte +12

Transformation of arachidonic acid and homo-gamma-linolenic acid by rabbit polymorphonuclear leukocytes. Monohydroxy acids from novel lipoxygenases

P Borgeat, Mats Hámberg, Bengt Samuelsson · Journal of Biological Chemistry · 1976 · 639 citations · Full text

Monohydroxy Acids, Biosynthesis, Lipid Metabolism +15

Prostacyclin (PGX) is the endogeneous metabolite responsible for relaxation of coronary arteries induced by arachidonic acid

Gregory J. Dusting, Salvador Moncada, John R. Vane · Prostaglandins · 1977 · 412 citations

Coronary Arteries, Biochemistry, Cardiovascular Disease +10