Mitochondrial respiratory chain activity in the human brain as a function of age

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Douglas C. Wallace · Science · 1992 · 1.3K citations

Degenerative Processes, Alzheimer's Disease, Mitochondrial Biogenesis +14

MITOCHONDRIAL DNA MUTATIONS AS AN IMPORTANT CONTRIBUTOR TO AGEING AND DEGENERATIVE DISEASES

AnthonyW. Linnane, Takayuki Ozawa, S Marzuki et al. · The Lancet · 1989 · 1.2K citations

Genome Instability, Mitochondrial Function, Natural Sciences +8

Mitochondrial DNA deletions in human brain: regional variability and increase with advanced age

Marisol Corral‐Debrinski, Terzah M. Horton, Marie T. Lott et al. · Nature Genetics · 1992 · 883 citations

Neurodegenerative Diseases, Advanced Age, Brain Function +7

Oxidative damage to mitochondrial DNA shows marked age‐dependent increases in human brain

Patrizia Mecocci, Usha MacGarvey, A. Kaufman et al. · Annals of Neurology · 1993 · 756 citations

[42]Assessment of mitochondrial oxidative phosphorylation in patient muscle biopsies, lymphoblasts, and transmitochondrial cell lines

Ian A. Trounce, Yoon L. Kim, Albert S. Jun et al. · Methods in enzymology on CD-ROM/Methods in enzymology · 1996 · 743 citations

Muscle Function, Mitochondrial Disease, Biochemistry +11