Postcarotid Endarterectomy Improvement in Cognition Is Associated with Resolution of Crossed Cerebellar Hypoperfusion and Increase in <sup>123</sup>I-Iomazenil Uptake in the Cerebral Cortex: A SPECT Study

Abstract

Resolution of CCH and increase in (123)I-IMZ uptake in the ipsilateral cerebral cortex after CEA is associated with postoperative improvement in cognitive function. These results may indicate that cognitive impairment is related to a state of potentially reversible central benzodiazepine receptor downregulation in the cortex in response to transient ischemic attack or minor stroke.