Antidepressant, anxiogenic, and antinociceptive properties of levofloxacin in rats and mice

Validation of open : closed arm entries in an elevated plus-maze as a measure of anxiety in the rat

Sharon Pellow, Philippe Chopin, Sandra E. File et al. · Journal of Neuroscience Methods · 1985 · 5.8K citations

Social Sciences, Behavioral Sciences, Psychology +9

Depression: a new animal model sensitive to antidepressant treatments

Roger D. Porsolt, Manuel Pichon, M Jalfre · Nature · 1977 · 4.4K citations

Medicine, Neuroscience, Psychiatry +12

Behavioural despair in rats: A new model sensitive to antidepressant treatments

Roger D. Porsolt, Guy Anton, N. Blavet et al. · European Journal of Pharmacology · 1978 · 3.1K citations

Medicine, Behavioral Sciences, Neurobiology +13

Effects of alpha-adrenoceptor agonists and antagonists in a maze-exploration model of ?fear?-motivated behaviour

Sheila L. Handley, Siddika Mithani · Naunyn-Schmiedeberg s Archives of Pharmacology · 1984 · 960 citations

Medicine, Neuroscience, Pharmacology +13

Structure-epileptogenicity relationship of quinolones with special reference to their interaction with gamma-aminobutyric acid receptor sites

K Akahane, Masayasu Sekiguchi, T Une et al. · Antimicrobial Agents and Chemotherapy · 1989 · 158 citations

Medicine, Medicinal Chemistry, Pharmacology +12