Concepedia

Ethanol Induces Transforming Growth Factor‐α Expression in Hepatocytes, Leading to Stimulation of Collagen Synthesis by Hepatic Stellate Cells

Junji Kato, Yasuhiro Sato, Noriaki Inui, Yoichiro Nakano, Rishu Takimoto, Kohich Takada, Masayoshi Kobune, Ganji Kuroiwa, Sachie Miyake, Yutaka Kohgo,

Alcoholism Clinical and Experimental Research · 2003 · 32 citations · 32 references

DOI

Abstract

These results suggest that TGF-alpha derived from ethanol-exposed hepatocytes may contribute to the development of hepatic fibrosis in alcoholic liver diseases.

References

32

Human Hepatocellular Carcinoma Cell Lines Secrete the Major Plasma Proteins and Hepatitis B Surface Antigen

Barbara B. Knowles, Chin C. Howe, David P. Aden · Science · 1980 · 2K citations

Survival and Causes of Death in Cirrhotic and in Noncirrhotic Patients with Primary Hemochromatosis

Claus Niederau, Rudolf Fischer, Amnon Sonnenberg et al. · New England Journal of Medicine · 1985 · 1.1K citations

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TGFα overexpression in transgenic mice induces liver neoplasia and abnormal development of the mammary gland and pancreas

Chamelli Jhappan, C Stahle, Richard N. Harkins et al. · Cell · 1990 · 713 citations

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Activation of hepatic stellate cells by TGF alpha and collagen type I is mediated by oxidative stress through c-myb expression.

K S Lee, Martina Buck, K Houglum et al. · Journal of Clinical Investigation · 1995 · 535 citations · Full text

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Effects of platelet-derived growth factor and other polypeptide mitogens on DNA synthesis and growth of cultured rat liver fat-storing cells.

Massimo Pinzani, Loreto Gesualdo, Ghada Mohamed Sabbah et al. · Journal of Clinical Investigation · 1989 · 480 citations · Full text

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