Loading and Release of Drugs from Oxygen‐rich Plasma Polymer Coatings

Abstract

Abstract Low‐pressure plasma‐polymerized ethylene film coatings rich in bonded oxygen groups (L‐PPE:O) were deposited on poly(ethylene terephthalate; PET) in order to act as hosts for antimicrobial drugs. Increasing O 2 content in the ethylene (C 2 H 4 )/Ar–diluted oxygen (O 2 ) gas mixture reduced the deposition rate, but increased the concentration of bonded oxygen, [O], including that of carboxylic acid groups, [COOH], as determined by X‐ray photoelectron‐ (XPS) and Fourier transform infrared (FTIR) spectroscopies, and by toluidine blue O (TBO) assays. L‐PPE:O coatings took up and sustained the release of ciprofloxacin for several hours. Steric hindrance impeded vancomycin penetration into the cross‐linked L‐PPE:O coatings. Ciprofloxacin‐loaded L‐PPE:O coatings inhibited in vitro the growth of Staphylococcus aureus . Deposition of L‐PPE:O on medical devices may endow them with ability to prevent nosocomial infections. magnified image