In vivo antitumour efficacy of MGI-114 (6-hydroxymethylacylfulvene, HMAF) in various human tumour xenograft models including several lung and gastric tumours

Cancer statistics, 1998

Sarah Landis, Thomas S. Murray, S. Bolden et al. · CA A Cancer Journal for Clinicians · 1998 · 2.4K citations · Full text

American Cancer Society, Cancer Statistics, Epidemiology +10

Preclinical antitumor activity of 6-hydroxymethylacylfulvene, a semisynthetic derivative of the mushroom toxin illudin S.

John R. MacDonald, Charles C. Muscoplat, Daniel L. Dexter et al. · PubMed · 1997 · 109 citations

Chemoprevention Strategy, Metronomic Chemotherapy, Pharmaceutical Chemistry +18

(Hydroxymethyl)acylfulvene:  An Illudin Derivative with Superior Antitumor Properties

Trevor C. McMorris, Michael J. Kelner, Wen Wang et al. · Journal of Natural Products · 1996 · 109 citations

Medicinal Chemistry, Hl 60, Bioorganic Chemistry +14

Effects on DNA integrity and apoptosis induction by a novel antitumor sesquiterpene drug, 6-hydroxymethylacylfulvene (HMAF, MGI 114)

Jan M. Woynarowski, Cheryl Napier, Steven K. Koester et al. · Biochemical Pharmacology · 1997 · 100 citations

Medicinal Chemistry, Apoptosis Induction, Oncogenic Agent +11

Efficacy of HMAF (MGI-114) in the MV522 metastatic lung carcinoma xenograft model nonresponsive to traditional anticancer agents

Michael J. Kelner, Trevor C. McMorris, Leita A. Estes et al. · Investigational New Drugs · 1996 · 72 citations

Traditional Anticancer Agents, Medicine, Pharmacology +8