Concepedia

A phase II, multicenter, open‐label study evaluating dosing and preliminary safety and efficacy of canakinumab in systemic juvenile idiopathic arthritis with active systemic features

Nicolino Ruperto, Pierre Quartier, Nico Wulffraat, Patricia Woo, Angelo Ravelli, Richard Mouy, Brigitte Bader‐Meunier, Sebastiaan J. Vastert, Emanuele Noseda, Daniele D’Ambrosio,

Arthritis & Rheumatism · 2011 · 191 citations · 33 references

DOI

Abstract

Canakinumab has a promising preliminary safety and efficacy profile in this limited cohort. Based on the findings of this trial, further studies in a larger population of children with systemic JIA are warranted.

References

33

The CONSORT statement: revised recommendations for improving the quality of reports of parallel-group randomised trials

David Moher, Kenneth F. Schulz, Douglas G. Altman · The Lancet · 2001 · 5.4K citations · Full text

, , +7

International League of Associations for Rheumatology classification of juvenile idiopathic arthritis: second revision, Edmonton, 2001.

Ross E. Petty, T. R. E. Southwood, Prudence Manners et al. · PubMed · 2004 · 4.2K citations

, , +13

Revision of the proposed classification criteria for juvenile idiopathic arthritis: Durban 1997

Ross E. Petty, T. R. E. Southwood, John Baum et al. · 2001 · 1.2K citations

Preliminary definition of improvement in juvenile arthritis

Edward H. Giannini, Nicolino Ruperto, Angelo Ravelli et al. · Arthritis & Rheumatism · 1997 · 1K citations

Role of interleukin-1 (IL-1) in the pathogenesis of systemic onset juvenile idiopathic arthritis and clinical response to IL-1 blockade

Virginia Pascual, Florence Allantaz, Edsel Arce et al. · The Journal of Experimental Medicine · 2005 · 911 citations · Full text