Journal of the American Chemical Society · 2006 · 114 citations · 12 references
Life SciencesImmunologyMedicinal ChemistryDrug DiscoveryImmunotherapyInnate ImmunityGlycan StructureImmune Cell SignalingInflammatory SignalingLipid GlycosylationNatural Killer Cell BiologyNatural Killer Cell RegulationGlycolipid Function In ImmunityGlycolipid StructureGlycolipid-mediated Cell SignalingGlycolipid-mediated Signal TransductionLipid Glycosylation PathwaysNk Cell Activating LigandsStructural Glycobiology Of GlycolipidsStructure-based Target Discovery
Introduction of an aromatic group into the fatty acyl chain of alpha-GalCer modulates the activity and selectivity of IFN-gamma/IL-4 secretion through CD1d-mediated activation of NKT cells. Compound 14-16 are more potent than alpha-Galcer and biased for IFN-gamma than for IL-4. These new glycolipids may find use as adjuvants or as antimetastatic agents.
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Exogenous and endogenous glycolipid antigens activate NKT cells during microbial infections
Jochen Mattner, Kristin L. DeBord, Nahed Ismail et al. · Nature · 2005 · 1.1K citations
Recognition of bacterial glycosphingolipids by natural killer T cells
Yuki Kinjo, Douglass Wu, Gisen Kim et al. · Nature · 2005 · 916 citations