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Genetic variation in the PNPLA3 gene is associated with alcoholic liver injury in Caucasians
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2010
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GeneticsGenetic EpidemiologyHuman PolymorphismPathologyAlcoholic Liver InjuryFatty Liver DiseaseMetabolic SyndromeNonalcoholic Fatty Liver DiseaseFat ContentHealth SciencesLiver PhysiologyGenetic FactorGenetic VariationAlcohol-related Liver DiseaseEpidemiologyAlcoholic Liver DiseaseHepatologyPnpla3 GeneLiver DiseaseMedicine
Background and Aims: A recent genome-wide study revealed an association between variation in the PNPLA3 gene and liver fat content. In addition, PNPLA3 single nucleotide polymorphism (SNP) rs738409 (M148I) was reported to be associated with advanced alcoholic liver disease in alcohol-dependent individuals of Mestizo descent. We therefore evaluated the impact of rs738409 on the manifestation of alcoholic liver disease in two independent German cohorts.